THE DEFINITIVE GUIDE TO TRASTUZUMAB

The phosphorylated HER3 supplies docking websites for p85 subunit of PI3K. The completely activated PI3K sophisticated is generated by binding of p110 subunit of PI3K to p85 which can produce PIP3 by means of phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both of those threonine an